Implication du canal TRPA1 astrocytaire dans la pathogenèse de la maladie d’Alzheimer
Laboratories: GIN and IBS - 01/10/2022 - 30/09/2025Thesis project holders: Mireille Albrieux and Christophe MoreauYoung thesis researcher: Guillaume Audic Abstract: In the context of Alzheimer’s disease, dyshomeostasis caused by amyloid-β (Aβ) peptide is proposed as one of the early events of the disease and is associated with a disruption of neuronal activity. In the brain, neuronal activity is strongly regulated by astrocytes, which wrap around synapses to control their activity. Read more |
Designing atomically precise gold nanocluster architectures with DNA-guided self-assembly and biofunctionalization approaches
Thesis project holders: Xavier LE GUEVEL and Didier GASPARUTTO |
Post Stroke OSA: the effect of intermittent hypoxia on cerebrovascular recovery
Thesis project holders : Anne BRIANCON-MARJOLLET and Claire ROMEYoung thesis researcher : Bayan EL AMINE Abstract: Stroke affects 15 million people annually, often impairing cognitive function. Post-stroke recovery is prolonged, worsened by comorbidities like obstructive sleep apnea (OSA), which impacts 30% of patients. This thesis studied stroke-OSA interaction in rats where ischemic lesions were induced and exposed to hypoxic (IH) or normoxic (N) conditions... Read more |
Crosstalk between C1 and HMGB1 alarmin in inflammation
Thesis project holders: Véronique ROSSI and Thierry RABILLOUDYoung thesis researcher: Marie LORVELLEC Abstract: C1s protease initiates the classical complement pathway, previously thought to target only C2 and C4. Recent studies reveal that free active C1s has roles beyond complement activation, including targeting HMGB1. Initially recognized as a nuclear protein, extracellular HMGB1 drives inflammation. This work highlights that fragment f3, generated by C1s cleavage, inhibits pro-inflammatory cytokine secretion... Read more |
Investigation of the redox signaling involved in the chloroplast biogenesis
Thesis project holders: David COBESSI and Robert BLANVILLAINYoung thesis researcher: Soumiya SANKARI MUTHUKUMAR Abstract: The thesis investigated activity of the superoxide dismutases PAP4 and PAP9 from the PEP. The PEP envelope was calculated at 27,5 Å resolution, and the CSP41b 3D structure solved at 3.4 Å resolution. Its interaction with PRIN2 was investigated using biophysical experiments and tested in onion epidermal cells using bimolecular fluorescence complementation assay. Read more |
Telomeric response to potentiate new theranostic approach in ratio-resistant lung cancer cells Laboratories : IAB and DCM - 01/10/2020 - 01/10/2023Thesis project holders: Virgine FAURE et Olivier RENAUDETYoung thesis researcher: Sean MORO Abstract Our project was to overcome radioresistance in lung cancer cells by combining radiotherapy with a theranostic system using radiosensitizing gold nanoclusters (AuNCs) able to deliver siRNA targeting TRF2 protein, one of the key players in telomeric radioprotective response. Following the synthesis and characterization of the nanosystem, our results have shown that AuNCs were capable to interact with siRNA, to protect them and to deliver them... Read more |
Design of cell-permeable and fluorogenic delivery agents to extend the spectrum of antibiotic action
Thesis project holders: Yung-SIng WONG and Eric FAUDRY Young thesis researcher: Pascal MOSER Abstract: An important scientific need is to understand how a sufficient translocation of bioactive molecules across the Gram-negative cell wall can be assured. An original mean in this project was the use of cyclic peptides as carriers to improve antibiotics transport through the bacterial cell wall due to their remarkable mechanism of conformational changes (validated by computational modeling). Read more |
Optimization of electrochemical transduction using aptamers for the detection of arginine vasopressin in the picomolar range
Thesis project holders: Michael HOLZINGER and Corinne RAVELET |
Impact of intermittent hypoxia on wound healing in experimental models of diabetic foot ulcers
Thesis project holders: Matthieu ROUSTIT - Walid RACHIDI and Jean-Luc CRACOWSKI |
Fighting oxidative stress thanks to nisod mimics
Thesis project holders: Pascale DELANGLE and Carole DUBOC Young thesis researcher: Pawel GUINARD Abstract: The objective of this thesis was to create biomimetic complexes inspired by the nickel superoxide dismutases’ (Ni-SOD) active site to replicate its efficient antioxidant activity. These complexes are based on a pseudo-ATCUN scaffold (Amino-Terminal CuII and NiII binding motif), capable of reproducing the NiII geometry in the enzyme's active site. Read more |
