Laboratories :  DPM and IBS - 1/10/2019 – 09/02/2023

Thesis project holders : Yung-SIng WONG and Eric FAUDRY   
Young thesis researcher : Pascal MOSER 

Abstract: An important scientific need is to understand how a sufficient translocation of bioactive molecules across the Gram-negative cell wall can be assured. An original mean in this project was the use of cyclic peptides as carriers to improve antibiotics transport through the bacterial cell wall due to their remarkable mechanism of conformational changes (validated by computational modeling). Cyclic peptides, coupled with antibiotics, were synthesized in attempts to broaden the spectrum of antibiotics. We also designed a new promising self-immolative linker (SIL) aimed at delivering carboxylic antibiotics inside the bacteria. This was explored by the development of a selective redox-sensitive fluorogenic SILs to detect the release of carboxylic acids inside bacteria.