Laboratories : Symmes and CIC - 01/01/2019 – 31/03/2023

Thesis project holders : Matthieu ROUSTIT - Walid RACHIDI and Jean-Luc CRACOWSKI
Young thesis researcher : Clément CALISSI

Abstract: We hypothesised that microvascular dysfunction caused by intermittent hypoxia (IH) may potentiate diabetes-related impairment in wound healing. In healthy mice exposed to IH, we observed delayed healing of excisional ulcers, without impairment in skin perfusion or endothelium-dependent microvascular dysfunction. In diabetic mice, there was no additional impact of IH on wound healing, skin perfusion and reactivity. Peri-ulcer perfusion throughout the healing process, as well as neoangiogenesis, were also not impacted. We further tested this hypothesis in a patient-derived cellular model, with similar results.
In conclusion, our results suggest that chronic IH does not have deleterious additive effects on the cutaneous microcirculation in diabetes.



Publications :
Couturier A, Calissi C,. et al. (2023), Mouse models of diabetes-related ulcers: A systematic review and network meta-analysis’, eBioMedicine, 98, p. 104856.