Laboratories : SyMMES and DCM - 01/10/2020 – 31/12/2023

Thesis project holders : Pascale DELANGLE and Carole DUBOC 
Young thesis researcher : Pawel GUINARD

Abstract: The objective of this thesis was to create biomimetic complexes inspired by the nickel superoxide dismutases’ (Ni-SOD) active site to replicate its efficient antioxidant activity. These complexes are based on a pseudo-ATCUN scaffold (Amino-Terminal CuII and NiII binding motif), capable of reproducing the NiII geometry in the enzyme's active site.

The obtained results have identified two reaction intermediates formed during the dismutation of superoxide by one of these complexes, providing valuable insights into the enzyme mechanism. Additionally, through the identification of factors enhancing SOD activity, highly efficient complexes have been developed, showing potential as antioxidant agents within cells.



Publications :
-"A Series of Ni Complexes Based on a Versatile ATCUN-Like Tripeptide Scaffold to Decipher Key Parameters for Superoxide Dismutase Activity", J. Domergue, P. Guinard, M. Douillard, J. Pecaut, S. Hostachy, O. Proux, C. Lebrun, A. Le Goff, P. Maldivi, C. Duboc, P. Delangle, Inorganic Chemistry, 2023, 62, 8747-8760.
-"A Bioinspired Ni-II Superoxide Dismutase Catalyst Designed on an ATCUN-like Binding Motif", J. Domergue, P. Guinard, M. Douillard, J. Pecaut, O. Proux, C. Lebrun, A. Le Goff, P. Maldivi, P. Delangle, C. Duboc, Inorganic Chemistry, 2021, 60, 12772-12780.