Laboratories : HP2 and GIN - 01/10/2021 – 30/09/2024

Thesis project holders : Anne BRIANCON-MARJOLLET and Claire ROME
Young thesis researcher : Bayan EL AMINE

Abstract: Stroke affects 15 million people annually, often impairing cognitive function. Post-stroke recovery is prolonged, worsened by comorbidities like obstructive sleep apnea (OSA), which impacts 30% of patients. This thesis studied stroke-OSA interaction in rats where ischemic lesions were induced and exposed to hypoxic (IH) or normoxic (N) conditions from 4 to 56 days. MRI showed BBB permeability and vascular changes in IH. Molecular analyses revealed increased IL6, VEGF and VEGFR1 in HI brains, IHC on brain showed decreased NeuN and increased GFAP, while metabolomics showed reduced alanine and betaine. SAS moderately disrupts brain recovery by altering vasculature, gene expression, and metabolism.

Publications:
Cerebral oxidative stress, inflammation and apoptosis induced by intermittent hypoxia: a systematic review and meta-analysis of rodent data. El Amine B, Fournier J, Minoves M, Baillieul S, Roche F, Perek N, Pépin JL, Tamisier R, Khouri C, Rome C, Briançon-Marjollet A. Eur Respir Rev. 2024 Dec18;33(174):240162. doi:10.1183/16000617.0162-2024.
 

Co-authorship group significantly impacts reported arterial blood pressure variations in rodents exposed to intermittent hypoxia: a meta-research study. Khouri C, El Amine B, Arnaud C, Belaidi E, Boete Q, Godin-Ribuot D, Levy P, Faury G, Harki O, Cracowski JL, Briançon-Marjollet A, Pepin JL, Cardiovasc Res. 2023 May 2;119(4):e128-e130. doi: 10.1093/cvr/cvad048.