Perrine Beria - DCM and LCBM

Thesis: Peptide functionalized responsive lanthanide complexes as bioprobes for CEST imaging (PRECEST)
 

Abstract: This thesis focuses on macrocyclic lanthanide complexes containing peptides and radical species as redox switchs in CEST imaging.

"I am Perrine, a first year PhD student in organic chemistry with a focus on lanthanide-based bioprobes for medical imaging. My previous work on bimodal redox-active complexes led me to this topic, where we aim to improve the solubility and stability in aqueous media of the molecules from my master project, while improving their CEST and redox response. I am particularly interested in understanding how structural modifications influence CEST properties and redox behavior.

We chose the EUR CBS because it directly supports and funds inter-laboratory collaborations. This is essential for my project, which relies on a strong partnership between the LCBM and the DCM to combine expertise in organic and inorganic synthesis, and biological applications.

After my PhD, I plan to remain in academia to pursue a career as an associate professor, continuing to develop magnetic bioprobes."