Onésie Larrière - HP2 and LBFA 

Thesis: Blood Flow Restriction: a novel approach to potentiate the effects of rehabilitative exercise training in COPD?

Abstract: Investigating how blood flow restriction training enhances muscle function, molecular adaptations, and exercise tolerance in COPD patients using low-load resistance exercise.

"My name is Onésie Larrière, and I recently began my PhD in early November 2025 within the HP2 and LBFA laboratories. I hold a Master’s degree in Adapted Physical Activity and Health (STAPS APA-S), which strengthened my interest in improving physical function in clinical populations through tailored and accessible training methods. This background naturally led me to focus on blood flow restriction (BFR) training, a promising approach that can enhance muscle strength and mass with very low exercise loads—an essential advantage for patients with chronic obstructive pulmonary disease (COPD), who often have difficulty tolerating traditional resistance training.

My project aims to clarify the muscular, cardiovascular, molecular, and epigenetic mechanisms underlying BFR-induced adaptations and to identify how these mechanisms can support rehabilitation in vulnerable populations. I chose EUR CBS for its strong interdisciplinary environment and high-quality research network. After my PhD, I aim to pursue a career in research to contribute to evidence-based and patient-centered rehabilitation strategies. "